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Tigel (Ethiopia) Name of sport (game): Tigel. Place of practice (continent, state, nation): Ethiopia. Sources of information : Video: https://www.youtube.com/watch?v=dO7aAlACJu4&fbclid=IwAR19PH_MzPP6C4LMF8Wkj8Yo1mne_Mq6bH7iWvdOY2KviRM9gEk9wGiMxtE. https://www.youtube.com/watch?v=jfML4QuA6AU. https://www.youtube.com/watch?v=dO7aAlACJu4.

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How Tigel works. Tigel is a P2Y 12 receptor antagonist.. The P2Y 12 receptor couples with Gα i2 and other G i proteins which inhibit adenylyl cyclase. G i mediated signalling also activates PI3K, Akt, Rap1b, and potassium channels. The downstream effects of these activities mediate hemostasis and lead to platelet aggregation. Antagonism of the P2Y 12 receptor reduces development of occlusive ...

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